IQ Plus

IQ Plus™

• Supports brain nutrition for healthy neurological development
• Nourish the Mind – Empower the Future

Why Brain Nutrition Matters

• Early childhood and adolescence are critical windows for brain development.
• Nutrient deficiencies can impact cognitive function, focus, and learning abilities.
• IQ Plus™ provides scientifically backed ingredients to support brain health and neurotransmitter balance.

Serving Size: Each 10 ml syrup contains:

Servings Per Container: [75 ml]

Nutrient/Ingredient	Amount Per Serving	٪ القيمة اليومية (DV)
Acetyl L-Carnitine HCl	235.8 mg	–
Citicoline (CDP-Choline)	500 mg	–
Thiamine Mononitrate (Vitamin B1)	1.48 mg	123%
Riboflavin (Vitamin B2)	1.3 mg	100%
Pyridoxine HCl (Vitamin B6)	2.06 mg	121%
Cyanocobalamin (Vitamin B12)	2.4 mcg	100%
Omega-3 (Fish Oil, providing EPA/DHA)	500 mg	–
Coenzyme Q10 (CoQ10)	50 mg	–
Cholecalciferol (Vitamin D3, 40,000,000 IU/g)	20 mcg (800 IU)	100%
Phylloquinone (Vitamin K1)	120 mcg	100%
d-alpha-Tocopherol Acid Succinate (Vitamin E)	18.4 mg	123%
Zinc Sulfate (Elemental Zinc)	7.4 mg	67%
Walnut flavor	25 mg	–

Recommended Dosage:

• Children (3-6 years): ½ teaspoon (2.5 mL) Once or Twice daily
• Children (6+ years): 1 teaspoon (5 mL) Once or Twice daily

Route of administration: Oral & can be taken directly with water or juice.

The Role of Key Nutrients in Neurodevelopmental Disorders: Mechanisms of Action and CHOLINE Augmentation

Neurodevelopmental disorders (NDDs), such as autism spectrum disorder (ASD), attention deficit disorder (ADD), and learning disabilities, are characterized by cognitive, behavioral, and motor impairments. These conditions often involve mitochondrial dysfunction, neurotransmitter imbalances, oxidative stress, and neuroinflammation.

Several bioactive compounds, including acetyl L-carnitine, citicoline, B vitamins, omega-3 fatty acids, coenzyme Q10, and minerals like zinc, have been studied for their potential in modulating neuronal energy metabolism, neurotransmitter synthesis, antioxidant protection, and neuroimmune regulation. This report explores the mechanisms of action of these ingredients, focusing on CHOLINE augmentation, a crucial factor in maintaining excitatory-inhibitory balance in the brain.

The combination of neuroprotective, mitochondrial-supporting, and neurotransmitter-modulating nutrients plays a critical role in supporting brain development, cognitive function, and behavioral regulation in children with NDDs. Specifically, the augmentation of CHOLINERGIC neurotransmission helps counteract inattention, a common issue in conditions like ADD and ASD.

Targeted nutritional supplementation could serve as an adjunctive therapy alongside conventional treatments, providing a holistic, evidence-based approach to neurodevelopmental support

Nutraceuticals such as Vitamin B6, Omega-3s, Citicoline, and Coenzyme Q10 provide sustainable CHOLINE enhancement with low risk of side effects. While pharmaceutical agents like Vigabatrin, Diazepam, and Memantine offer rapid, potent effects, they are often associated with tolerance, dependence, and cognitive impairment.

For mild-to-moderate cases of NDDs, nutritional strategies may serve as adjunct therapies, reducing reliance on pharmacological interventions. However, severe cases or treatment-resistant symptoms may require pharmaceutical agents.

Mechanisms of Action of Key Ingredients

Energy Metabolism and Mitochondrial Function

Mitochondrial dysfunction has been implicated in neurodevelopmental disorders, leading to impaired ATP production and neuronal stress.

• Acetyl L-Carnitine (ALC): Facilitates fatty acid transport into mitochondria, enhancing ATP production and neuronal energy availability (Calabrese et al., 2021).
• Coenzyme Q10 (CoQ10): An essential electron transporter in the mitochondrial electron transport chain (ETC), protecting against oxidative stress and improving ATP synthesis (González-Casacuberta et al., 2022).
• Riboflavin (Vitamin B2): Acts as a cofactor for flavoproteins, essential for mitochondrial metabolism and reducing oxidative stress (Ashrafi et al., 2018).
• Thiamine (Vitamin B1): Involved in pyruvate metabolism and mitochondrial function, which is essential for neuronal energy homeostasis (Sredni et al., 2020).

✅ Impact on Neurodevelopment: Enhancing mitochondrial function improves cognitive function, reduces fatigue, and supports neuroplasticity.

Neurotransmitter Synthesis and Synaptic Plasticity

Neurodevelopmental disorders are often associated with deficiencies in key neurotransmitters like dopamine, acetylcholine, and Norepinephrine.

• Citicoline: Provides choline for acetylcholine synthesis and stabilizes neuronal membranes via phosphatidylcholine production (Secades & Lorenzo, 2021).
• Pyridoxine (Vitamin B6): A critical coenzyme for neurotransmitter metabolism, including dopamine, serotonin, and CHOLINE synthesis via glutamate decarboxylase (GAD) (Kennedy, 2016).
• Cyanocobalamin (Vitamin B12): Essential for myelin sheath maintenance and neuronal function, indirectly supporting neurotransmission (Obeid et al., 2019).
• Omega-3 Fatty Acids (EPA/DHA): Modulate dopaminergic and serotonergic pathways, promoting synaptic plasticity and neuronal survival (Bazinet & Layé, 2014).

✅ Impact on Neurodevelopment: Enhancing neurotransmitter levels improves memory, attention, and learning processes.

Antioxidant and Neuroprotective Effects

Oxidative stress plays a key role in neuronal damage and inflammation in NDDs.

• d-alpha-Tocopherol Acid Succinate (Vitamin E): A potent lipophilic antioxidant, protecting neuronal membranes from lipid peroxidation (Morris et al., 2018).
• Coenzyme Q10: Reduces mitochondrial ROS production, preserving neuronal integrity (González-Casacuberta et al., 2022).
• Omega-3 Fatty Acids: Suppress neuroinflammatory pathways by reducing pro-inflammatory cytokines (Bazinet & Layé, 2014).
• Zinc Sulphate: Modulates oxidative stress pathways and supports neuronal repair (Levenson, 2021).

✅ Impact on Neurodevelopment: Antioxidants protect against cognitive decline and neuroinflammation, enhancing brain function.

Clinical Trial Evidence

Nutritional Compounds and CHOLINE Enhancement in NDDs

Vitamin B6 and Autism

• Study: Adams et al. (2011) conducted a double-blind, placebo-controlled trial in autistic children supplemented with Vitamin B6 and Magnesium.
• Findings: Significant improvements in social interaction, communication, and reduced irritability.
• Mechanism: Enhanced CHOLINE synthesis via GAD activation.
• Reference: Adams JB, et al. BMC Pediatr. 2011;11:54. DOI: 10.1186/1471-2431-11-54.

Omega-3 Fatty Acids and ADD

• Study: Bloch & Qawasmi (2011) performed a meta-analysis on Omega-3 supplementation in ADD.
• Findings: Moderate improvement in attention and hyperactivity, particularly with high DHA doses.
• Mechanism: Increased CHOLINE receptor expression, reduced inflammation.
• Reference: Bloch MH, Qawasmi A. J Am Acad Child Adolesc Psychiatry. 2011;50(10):991-1000. DOI: 10.1016/j.jaac.2011.06.008.

Coenzyme Q10 and Mitochondrial Dysfunction in ASD

• Study: Gvozdjáková et al. (2020) assessed CoQ10 in ASD patients with mitochondrial dysfunction.
• Findings: Improved cognitive performance and reduced oxidative stress markers.
• Mechanism: Protection against glutamate excitotoxicity, stabilizing CHOLINERGIC tone.
• Reference: Gvozdjáková A, et al. Neuro Endocrinol Lett. 2020;41(4):211-217.